Melanotan IIMelanotan II

Melanotan II Peptide Information

What is Melanotan II?

Melanotan II

Melanotan II, commonly referred to as Melanotan 2, is an analogue of the endogenous alpha-melanocyte stimulating hormone (α-MSH) and is composed of seven amino acids. Melanotan II was originally developed by scientists at the University of Arizona as a possible preventative treatment to combat the harmful effects of UV radiation exposure caused by sunlight. These scientists hypothesized that the exogenous melanotan could stimulate melanogenesis, which would then lead to the production of melanin to form a protective barrier from the UV rays emitted by the sun. Further scientific studies have shown that Melanotan II could quite possibly be a thousand times more powerful than endogenous (natural) α-MSH at stimulating melanogenesis and may also stimulate other melanocortin receptors, namely MC1, MC3 and MC4.

Melanotan II has been thought to dramatically increase natural melanogenesis, which is a process that occurs when cells produce a pigment known as melanin that is found in the skin, eyes, and hair. Melanogenesis leads to a long-lasting pigmentation, which is in contrast to the pigmentation that originates from oxidation of already-existing melanin. The positive results gleaned from Melanotan II administration have encouraged further research into the development of this peptide and others for theoretical future functional therapeutic utilization. At we are fervently engaged in the quest to uncover these exciting possibilities and we are dedicated to doing our utmost to provide only the best quality Melanotan II in order to unlock the potential of this extraordinary peptide.

The Development of Melanotan II

Melanotan II was first created by a group of scientists at the University of Arizona under the leadership of Victor J. Hruby and Mac E. Hadley. These scientists were studying a peptide known as α-MSH, which elicited melanogenic effects. During the endeavor of tying to uncover a cure for skin cancer, these researchers knew that natural activation of endogenous melanin production was a very promising theoretical preventative remedy. After screening numerous molecular peptide compounds and endless hours of synthesis, they had discovered Melanotan-1. Through further alterations of the newly discovered sequence they also created Melanotan-II, which was found to be more potent in comparison to α-MSH.

Melanotan II Structural Data and Molecular Composition

Melanotan-II is a cyclic heptapeptide composed of seven amino acids linked by peptide bonds and is an analogue of alpha-melanocyte stimulating hormone (α-MSH). The amino acids that Melanotan II is composed of are N-Acetyl-L-norleucyl-L-alpha-aspartyl-L-histidyl-D-phenylalanyl-L-arginyl-L-tryptophyl-L-lysinamide (2->7)-lactam. This structure allows Melanotan II to bind and activate the melanocortin receptors located in both humans and animals. These receptors are responsible for numerous physiological functions including melanogenesis, the natural creation of melanin (pigment) by melanocytes. The molar mass of Melanotan II is 1024.180 Dalton and the molecular formula is C50H69N15O9.

Melanotan II Reconstitution, Solubility & Peptide Stability

Melanotan II should be reconstituted in pure H2O at a ratio not less than 5mg peptide per 1mL of water. This ratio allows for the Melanotan II peptide to dissolve fully in the aqueous solution. Prior to reconstitution, Melanotan II will remain stable when kept at room temperature and out of direct sunlight for up to 3-4 weeks. For long term storage it is best to keep the lyophilized Melanotan II frozen at approximately -18C. Once reconstituted, the melanotan peptide should be kept refrigerated and out of direct sunlight and will remain stable for 30-45 days. It is best practice to prevent freeze-thaw cycles and to always keep the peptide out of direct exposure to sunlight as this may accelerate degradation of the peptide bonds.